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Is Non-Gonoccocal Urethritis (NGU) Treated?

November 8, 2018

Question: What’s Non-Gonococcal Urethritis (NGU) Treated?


Most instances of Non-Gonococcal Urethritis (NGU) are undiagnosed chlamydia infections. Consequently, the very first line of treatment for NGU is just like the treatment for chlamydia.

If that NGU treatment doesn’t function, and you took all of your medicine as instructed, your doctors will need to investigate further.

The next step is to allow them to test you for a trichomoniasis infection. In case that evaluation is adverse, you may not get a clear response. (Often NGU is Brought on by mycoplasma, but that is only rarely analyzed for)

If your physician can not identify exactly what the source of the disease is, they will normally treat you with among the medication below. This is because a number of the bacteria that cause urethritis can be difficult to identify. Therefore, treating NGU this way is an effective means to eliminate the most common suspects.

Note: The medication regimens below are taken from the Centers for Disease Control 2015 STD treatment plans. Bear in mind that only your doctor can say which treatment is ideal for you.

Recommended Regimens for Initial NGU Treatment
Azithromycin 1 g orally in a single dose
Doxycycline 100 mg orally twice per day for 7 days Option Regimens
Erythromycin base 500 mg orally four times a day for 7 days
Erythromycin ethylsuccinate 800 mg orally four times a day for 7 days
Levofloxacin 500 mg orally once daily for 7 times
Ofloxacin 300 mg orally twice a day for Seven Days

Sometimes these treatments are ineffective. That is often because the disease is caused by a parasitic or fungal infection, such as trichomoniasis. (Sometimes the parasitic disease is also to a bacterial disease!) Therefore, if the initial treatment fails, physicians will try different options.

Recommended Regimens for Men with NGU Where Initial Treatment Was Not Successful

Metronidazole 2 g orally in one dose
Tinidazole 2 g orally in a single dose
Azithromycin 1 gram orally in one dose (if not used for initial treatment)
Moxifloxacin 400 mg orally once daily for 7 days (if azithromycin was utilized for first therapy.) 

The azithromycin and moxifloxacin are used because they are more likely to work against mycoplasma than some other medications. The moxifloxacin, particularly, is a rather new recommendation. From the time the 2015 treatment recommendations were released, mycoplasma were regarded as a significant source of NGU. Thus, aiming treatment at mycoplasma was regarded as significant after a first treatment failure. But, CDC has found that higher dose azythromycin is not helpful in curing mycoplasma. That’s why they urge moxifloxacin as Opposed to a second form of azithromycin treatment for NGU

In contrast, metronidazole and tinadazole are utilized to treat potential trichomoniasis infections. Testing isn’t universally available with this infection in men. 

Please Note: You must normally stop having sex while on treatment. This lessens the chance that you and your spouse will pass a disease back and forth. Any normal sexual partner should also be referred for treatment & testing when you are diagnosed with an STD.